George Edward Waddell (October 13, 1876 – April 1, 1914) was an American southpaw pitcher in Major League Baseball. In his thirteen-year career he played for the Louisville Colonels (1897, 1899), Pittsburgh Pirates (1900–01) and Chicago Orphans (1901) in the National League, and the Philadelphia Athletics (1902–07) and St. Louis Browns (1908–10) in the American League. Waddell earned the nickname "Rube" because he was a big, fresh kid. The term was commonly used to refer to hayseeds or farmboys. He was born in Bradford, Pennsylvania.
Waddell was elected to the Baseball Hall of Fame in 1946.
Waddell, a remarkably dominant strikeout pitcher in an era when batters mostly slapped at the ball to get singles, had an excellent fastball, a sharp-breaking curve, a screwball, and superb control (his strikeout-to-walk ratio was almost 3-to-1). He led the Major Leagues in strikeouts for six consecutive years.